Laboratory solutions

BostonGene’s assay portfolio integrates multiple molecular profiling techniques that can be customized and applied according to research and development needs, providing a comprehensive and detailed understanding of the underlying biology of the disease.
Next-generation sequencing
Whole exome sequencing (WES)
WES analysis identifies disease-related genetic alterations, providing molecular profile of the disease that can be used to develop personalized treatment options.
Whole transcriptome sequencing (RNA-seq)
RNA-seq analysis provides a comprehensive view of mRNA expression profiles and uncovers the intensity of pathogenic processes.
Immune repertoire sequencing
Immune repertoire sequencing from FFPE samples delivers an immune system analysis with data that has comparable quality to analysis performed with fresh tissue.
Single-cell RNA-seq (scRNA-seq)
Cellular heterogeneity analysis using the single-cell RNA-seq service provides insight into gene expression at the individual cell level.
Immunological assays
Cellular immunoprofiling (flow cytometry)
Cellular immunoprofiling using high-resolution flow cytometry provides an in-depth analysis of cellular populations and immune responses, enabling a detailed understanding of disease states and therapeutic targets.
Malignant cell profiling/mrd (flow cytometry)
Detecting minimal residual disease (MRD) with high sensitivity and specificity using flow cytometry improves disease monitoring and helps personalize cancer treatment options.
Cell sorting – custom facs and sequencing
Custom fluorescence-activated cell sorting (FACS) and sequencing solutions enable precise isolation and analysis of target cell populations.
Cell sorting – magnetic cell enrichment strategies
Magnetic cell enrichment strategies allow isolation of target cell populations for downstream applications, including functional analysis.
Next-generation liquid biopsy
ctDNA (plasma)
ctDNA analysis provides detection of clinically relevant gene alterations for disease progression and treatment response monitoring and is easily integrated with BostonGene’s WES mutation calling pipeline.
cfRNA (plasma)
Advanced analysis of RNA transcripts released into circulation by tumor cells and other diseased tissues unlocks comprehensive insights into disease states and treatment responses.
TCR/BCR-seq (Blood)
TCR/BCR-seq provides information on immune repertoire diversity and functionality.
Multiparameter imaging
H&E histology (tissue)
H&E histological analysis enables precise identification of a tissue’s structures, allowing accurate diagnosis and characterization of pathological changes in tissue samples.
Immunohistochemistry (tissue)
Immunohistochemistry (IHC) service provides solutions for a wide range of quantitative image analysis requirements featuring high-resolution imaging and accurate detection of specific IHC biomarkers in tissue samples.
Spatial proteomics, multiplex immunofluorescence (tissue)
Multiplex immunofluorescence (MxIF) assays simultaneously detect multiple markers with single-cell resolution and provide advanced analytics of tissue architecture based on cell-to-cell interactions.