BostonGene Announces Two Presentations at the 62nd American Society of Hematology Annual Meeting and Exposition

Presentations Highlight the Integral Role of Tumor Microenvironment Analysis in Determining Cellular Composition and Gene Expression for Patients with Follicular Lymphoma

WALTHAM, MA, December 1, 2020 — BostonGene Corporation, a biomedical software company committed to defining optimal precision medicine-based therapies for cancer patients, today announced that two abstracts were selected for poster presentations at the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition.  The all-virtual event will be held from December 5 – 8, 2020.

Details of the presentations are below:

Title: Integration and Iteration: Using Advanced, High-Content Imaging and Single-Cell Gene Expression Analysis to Uncover Unique Aspects of Follicular Lymphoma Biology
Session: 621: Lymphoma—Genetic/Epigenetic Biology: Poster I
Abstract Number: 1106
Date and Time: Saturday, December 5, 2020: 10:00 AM – 6:30 PM ET
Presenter: Andrea J. Radtke, PhD, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)

Follicular lymphoma is an indolent B-cell lymphoma with remarkable heterogeneity in disease progression and trajectory; therefore, determining the cell intrinsic and extrinsic factors underlying this clinical heterogeneity is necessary to impact patient clinical outcomes. Using a multi-omics approach, including whole exome sequencing (WES) and bulk RNA-seq integrated with single-cell analyses such as scRNA-seq and multiparameter imaging, notable patient-specific cellular interactions and expression patterns were identified that may drive cancer patient survival. This integrated approach provides insights into both tumor biology and disease trajectory, which can ultimately benefit therapeutic strategies in follicular lymphoma.

Research conducted with the National Cancer Institute (NCI) and the National Institute of Allergy and Infectious Diseases (NIAID), both part of the National Institutes of Health (NIH).

Title: High Dimensional Tissue-Based Spatial Analysis of the Tumor Microenvironment of Follicular Lymphoma Reveals Unique Immune Niches inside Malignant Follicles
Session: 622
Abstract Number: 1117
Date and Time: Saturday, December 5, 2020: 10:00 AM – 6:30 PM ET
Presenter: Jose C. Villasboas, MD, Mayo Clinic

Cells of the immune system play an important role in modulating the trajectory of lymphomas; therefore, understanding the composition and spatial distribution of immune cells within the tumor microenvironment (TME) is critical to improve clinical outcomes for patients. Analysis of a follicular lymphoma tumor section that used Co-Detection by Indexing (CODEX) multiplex immunofluorescence image processing identified unique cell subsets and specific spatial distribution of immune cells. These insights into the complex immune cell composition and architecture of the TME add to the prognostic value of the TME as a therapeutic target in follicular lymphoma.

Research conducted with Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Mayo Clinic, Memorial Sloan Kettering Cancer Center, Université Claude Bernard Lyon and the University of Iowa.

In addition to the poster presentations, the abstracts have been published online in the November supplemental issue of “Blood”.

For more information, please visit the 62nd ASH Annual Meeting and Exposition website at https://www.hematology.org/meetings/annual-meeting/abstracts.

 

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About BostonGene Corporation

BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient’s individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGene’s mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies. For more information, visit BostonGene at http://www.BostonGene.com.

 

Media Contacts:

BostonGene
Erin O’Reilly
+1-781-366-7049
Erin.Oreilly@BostonGene.com

BostonGene and Thomas Jefferson University Announce Research Collaboration

A Study to Identify Predictive Correlates and Biomarkers of Response for Patients with Head & Neck Cancer

WALTHAM, MA – November 10, 2020 – BostonGene Corporation, a biomedical software company committed to defining optimal precision medicine-based therapies for cancer patients, today announced a research collaboration with Thomas Jefferson University and the Sidney Kimmel Cancer Center – Jefferson Health for a study from the window of opportunity trial of Nivolumab and Tadalafil for patients with squamous cell carcinoma of the head and neck.

The Sidney Kimmel Cancer Center – Jefferson Health, a National Cancer Institute (NCI)-designated clinical cancer center providing cancer care at Thomas Jefferson University Hospital, based in Philadelphia, Pennsylvania, is a clinical and research enterprise with four advanced care hubs located throughout the Greater Philadelphia region and staffed by hundreds of oncology researchers and physicians from around the globe.

The research collaboration aims to evaluate the molecular, cellular and immunologic profiles of head and neck cancer patients treated with Nivolumab and Tadalafil.  As part of the collaboration, BostonGene will apply its integrated whole exome and whole transcriptome analysis to simultaneously assess the activity of the tumor and tumor microenvironment of patients at distinct disease stages ranging from localized to metastatic disease.  The analysis will include the identification of significant somatic alterations, evaluation of gene expression patterns, estimation of tumor heterogeneity, TCR and BCR repertoires and microenvironment classification among other molecular features.

“Leveraging BostonGene’s detailed analysis will allow us to comprehensively assess the molecular profile of head and neck cancer patients treated with Nivolumab and Tadalafil,” said Joseph Curry, MD, Member of the Sidney Kimmel Cancer Center and Associate Professor of Otolaryngology at Thomas Jefferson University. “Using a data analytical approach to evaluate the molecular portrait and tumor microenvironment composition will help us to predict the benefits of the particular combination therapy for each patient.”

“We are excited to work with Thomas Jefferson University and the Sidney Kimmel Cancer Center – Jefferson Health on this study of patients with head and neck cancer to demonstrate the clinical utility of BostonGene’s platform,” said Andrew Feinberg, President and CEO at BostonGene. “The collaboration will validate the use of comprehensive molecular analysis to correlate tumor activity and cellular composition with response to therapy, creating a significant opportunity to improve personalized care for patients with head and neck cancer.”

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About BostonGene Corporation

BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient’s individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGene’s mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies. For more information, visit BostonGene at http://www.BostonGene.com.

 

Media Contacts:

BostonGene
Erin O’Reilly
+1-781-366-7049
Erin.Oreilly@BostonGene.com

 

Transgene, NEC and BostonGene Announce Strategic Collaboration for Two Ongoing Clinical Trials for Patients with Ovarian and Head & Neck Cancers

Strasbourg (France), Tokyo (Japan) and WALTHAM, MA–Oct. 6, 2020Transgene (Euronext Paris: TNG), a biotech company that designs and develops virus-based immunotherapies for the treatment of cancer, NEC Corporation (NEC; TSE: 6701), a leader in IT and network technologies and BostonGene Corporation (BostonGene), a biomedical software company committed to defining optimal precision medicine-based therapies for cancer patients, today announced a strategic collaboration for two ongoing Phase 1 clinical trials of TG4050, an individualized therapeutic vaccine for ovarian and head & neck cancers based on Transgene’s proprietary myvac® platform and NEC’s AI-driven Neoantigen Prediction System in Europe and the United States.

Transgene’s myvac® platform brings together a series of highly innovative technologies, such as viral genome engineering, to achieve high-speed modular manufacturing of bespoke immunotherapies.

TG4050 is an individualized cancer vaccine based on the myvac® platform; it is based on an optimized viral platform for cancer vaccination and integrates NEC’s artificial intelligence capabilities. This therapeutic vaccine aims at stimulating the immune system of patients to induce a T-cell response against tumor-specific antigenic alterations, called neoantigens. These neoantigens are derived from genomic mutations and selected using NEC’s Neoantigen Prediction System, an advanced AI technology that has already been applied in the field of oncology. TG4050 has been designed to target up to 30 patient-specific neoantigens. Transgene is sponsoring two Phase 1 trials that are expected to deliver a first proof of concept of this virus-based individualized approach.

As part of the collaboration, BostonGene will conduct genomic and transcriptomic analyses of primary patient tumors collected from patients enrolled in these two clinical trials to identify predictors of response to TG4050 and the cancer cell-intrinsic and -extrinsic factors that may mediate each patient’s response to the vaccine. BostonGene’s platform integrates the genomic and transcriptomic analyses to simultaneously assess the activity of the tumor and the microenvironment through the identification of significant somatic alterations, evaluation of gene expression, estimation of tumor heterogeneity and classification of the microenvironment.

BostonGene generates a Tumor PortraitTM Report, involving the data-driven, visually appealing and self-explanatory tumor schematics elegantly depicting tumor activity, tumor cellular composition, and functionality of the immune-microenvironment and other tumor-associated processes. The comprehensive report will provide insights into the individual  oncogenic state and immunogenicity of the patient’s tumor.

“BostonGene’s unique solution and deep expertise in Next Generation Sequencing (NGS) analysis provide us with the detailed profiles of a tumor and its micro-environment. These Tumor Portrait™ Reports will help us look at our patient data in light of the current published evidence and could help us accelerate the development of TG4050,” said Éric Quéméneur, Pharm.D., Ph.D., Executive VP, Chief Scientific Officer of Transgene.  “This novel way of analyzing patient data is part of an ambitious translational program that supports the development of our myvac® platform. By integrating these types of approaches into our studies, we seek to build an integrated framework for the use of viral-based immunotherapeutics.”

“NEC looks forward to strengthening its collaboration with BostonGene through these trials of TG4050.   BostonGene’s advanced analysis of NGS among cancer patients provides excellent profiling that we believe will add important insight into the understanding of each patient’s tumor environment and how it reflects on the clinical outcomes of our treatment,” said Osamu Fujikawa, Senior Vice President at NEC Corporation.

“BostonGene is proud to support Transgene and NEC during these critical Phase 1 clinical trials,” said Nathan Fowler, MD, Chief Medical Officer at BostonGene. “This collaboration represents our ongoing commitment to improve immunotherapy options and transform personalization of treatment for cancer patients.”

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About TG4050
TG4050 is an individualized immunotherapy being developed for solid tumors that is based on Transgene’s myvac® technology and powered by NEC’s longstanding artificial intelligence (AI) expertise. This virus-based therapeutic vaccine encodes neoantigens (patient-specific mutations) identified and selected by NEC’s Neoantigen Prediction System. The prediction system is based on more than two decades of expertise in AI and has been trained on proprietary data allowing it to accurately prioritize and select the most immunogenic sequences.

TG4050 is designed to stimulate the immune system of patients in order to induce a T-cell response that is able to recognize and destroy tumor cells based on their own neoantigens. This individualized immunotherapy is developed for each patient and can be produced in a very short time frame.

This best-in-class candidate is being evaluated in two Phase 1 clinical trials for patients with ovarian cancers (NCT03839524) and HPV-negative head and neck cancers (NCT04183166).

About myvac®
myvac® is a viral vector (MVA) based, individualized immunotherapy platform that has been developed by Transgene to target solid tumors. myvac®-derived products are designed to stimulate the patient’s immune system, recognize and destroy tumors using the patient’s own cancer specific genetic mutations. Transgene has set up an innovative network that combines bioengineering, digital transformation, established vectorization know-how and unique manufacturing capabilities. Transgene has been awarded “Investment for the Future” funding from Bpifrance for the development of its platform myvac®. TG4050 is the first myvac®-derived product being evaluated in clinical trials.

About NEC’s Neoantigen Prediction System
NEC’s neoantigen prediction utilizes its proprietary artificial intelligence (AI), such as graph-based relational learning, which is combined with other sources of data to discover candidate neoantigen targets. NEC comprehensively evaluates the candidate neoantigens with a primary focus placed on its in-house major histocompatibility complex (MHC) binding affinity prediction trained on public and proprietary datasets. These allow NEC to effectively prioritize the numerous candidate neoantigens identified in a single patient.

About Transgene
Transgene (Euronext: TNG) is a publicly traded French biotechnology company focused on designing and developing targeted immunotherapies for the treatment of cancer. Transgene’s programs utilize viral vector technology with the goal of indirectly or directly killing cancer cells.

The Company’s clinical-stage programs consist of two therapeutic vaccines (TG4001 for the treatment of HPV-positive cancers, and TG4050, the first individualized therapeutic vaccine based on the myvac® platform) as well as two oncolytic viruses (TG6002 for the treatment of solid tumors, and BT-001, the first oncolytic virus based on the Invir.IO™ platform).

With Transgene’s myvac® platform, therapeutic vaccination enters the field of precision medicine with a novel immunotherapy that is fully tailored to each individual. The myvac® approach allows the generation of a virus-based immunotherapy that encodes patient-specific mutations identified and selected by Artificial Intelligence capabilities provided by its partner NEC.

With its proprietary platform Invir.IO™, Transgene is building on its viral vector engineering expertise to design a new generation of multifunctional oncolytic viruses. Transgene has an ongoing Invir.IO™ collaboration with AstraZeneca.

Additional information about Transgene is available at: www.transgene.fr.

Follow us on Twitter: @TransgeneSA

About NEC Corporation
NEC Corporation has established itself as a leader in the integration of IT and network technologies while promoting the brand statement of “Orchestrating a brighter world.” NEC enables businesses and communities to adapt to rapid changes taking place in both society and the market as it provides for the social values of safety, security, fairness and efficiency to promote a more sustainable world where everyone has the chance to reach their full potential. For more information, visit NEC at https://www.nec.com.

Transgene disclaimer
This press release contains forward-looking statements, which are subject to numerous risks and uncertainties, which could cause actual results to differ materially from those anticipated. The occurrence of any of these risks could have a significant negative outcome for the Company’s activities, perspectives, financial situation, results, regulatory authorities’ agreement with development phases, and development. The Company’s ability to commercialize its products depends on but is not limited to the following factors: positive pre-clinical data may not be predictive of human clinical results, the success of clinical studies, the ability to obtain financing and/or partnerships for product manufacturing, development and commercialization, and marketing approval by government regulatory authorities. For a discussion of risks and uncertainties which could cause the Company’s actual results, financial condition, performance or achievements to differ from those contained in the forward-looking statements, please refer to the Risk Factors (“Facteurs de Risque”) section of the Universal Registration Document, available on the AMF website (http://www.amf-france.org) or on Transgene’s website (www.transgene.fr). Forward-looking statements speak only as of the date on which they are made and Transgene undertakes no obligation to update these forward-looking statements, even if new information becomes available in the future.

About BostonGene Corporation

BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient’s individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGene’s mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies. For more information, visit BostonGene at http://www.BostonGene.com.

 

Media Contacts:

Transgene: Lucie Larguier

Director Corporate Communications & IR

+33 (0)3 88 27 91 04

investorrelations@transgene.fr

Media: Citigate Dewe Rogerson

David Dible/Sylvie Berrebi

+ 44 (0)20 7638 9571

transgene@citigatedewerogerson.com

NEC Corporation

Joseph Jasper
+81-3-3798-6511
j-jasper@nec.com

BostonGene

Erin O’Reilly
+1-781-366-7049
Erin.Oreilly@BostonGene.com

 

 

BostonGene and Top-Ranked U.S. Hospital to Collaborate on Cancer Research Study

BostonGene to Identify Biomarkers of Response to Oncolytic Virus Therapy in Patients with Recurrent Malignant Glioma

WALTHAM, MA – September 15, 2020 – BostonGene Corporation, a biomedical software company committed to defining optimal precision medicine-based therapies for cancer patients, today announced a scientific collaboration with Brigham and Women’s Hospital, a world-class academic medical center and a major teaching hospital of Harvard Medical School based in Boston, Massachusetts.

In this collaboration, BostonGene provides the analysis of whole transcriptome sequencing (RNA seq) data sets generated from tumor and blood samples from patients with recurrent glioblastoma (GBM) treated with an oncolytic virus as part of a Phase I clinical trial. As part of the effort, BostonGene correlation analysis aims to identify novel biomarkers of response to therapy. The collaboration will further demonstrate the powerful advantages of transcriptomic data analysis for prediction of the response to novel therapies for malignant brain tumors.

“We are very excited to enter into this collaboration with BostonGene in our efforts to fully understand the molecular underpinnings of responses to novel engineered viruses-based therapies,” said Ennio Antonio Chiocca, MD, PhD, Neurosurgeon-in-Chief and Chairman, Department of Neurosurgery at Brigham and Women’s Hospital. “This collaboration is another step in allowing us to make better individual treatment decisions for patients with GBM.”

“We’re honored to collaborate with Brigham and Women’s Hospital to demonstrate the clinical utility of BostonGene’s analytical tools that have been designed to improve diagnosis and treatment decisions for cancer patients,” said Andrew Feinberg, President & CEO at BostonGene.  “We firmly believe that advanced computational analytics will better equip physicians as they identify personalized treatment plans.”

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About BostonGene Corporation

BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient’s individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGene’s mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies. For more information, visit BostonGene at http://www.BostonGene.com.

 

Media Contacts:

BostonGene
Erin O’Reilly
+1-781-366-7049
Erin.Oreilly@BostonGene.com

BostonGene Announces Scientific Collaboration with Leading Cancer Center

Sophisticated Data Analytics to Predict Drug Response and Identify New Biomarkers in T-cell Lymphomas

WALTHAM, MA – August 4, 2020 – BostonGene Corporation (BostonGene), a biomedical software company focused on defining optimal precision medicine-based therapies for cancer patients, today announced its collaboration with The Weinstock Laboratory, a translational research program focused on novel therapeutics for lymphoid malignancies, at Dana-Farber Cancer Institute, Inc.  The collaboration aims to define predictors of response to PI3 kinase inhibition in relapsed/refractory T-cell lymphomas.

The Weinstock Laboratory is leading the research efforts to reveal mechanisms of response and resistance, and possible cause of adverse effects to Duvelisib (PI3K delta & gamma inhibitor) in patients with T-cell lymphomas (TCLs).  Their work is supported by the Leukemia and Lymphoma Society and by Verastem, the makers of Duvelisib.  In this collaboration, BostonGene provides advanced computational analytics of genomic, transcriptomic, proteomic and multiplex imaging data sets to predict drug response and identify new biomarkers.  BostonGene’s software uses a set of unique deconvolution algorithms that reveal cellular content of a tumor and surrounding microenvironment using transcriptome next generation sequencing (NGS) data, and image analysis algorithms to elucidate spatial parameters of tumor microenvironment  distribution using immunofluorescence (IF) imaging data.

“We are excited to collaborate with BostonGene,” said David Weinstock, MD, at Dana- Farber Cancer Institute, Inc. “Improving patient outcomes is our top priority and by partnering with BostonGene we hope to accurately predict which patients will benefit from treatment by identifying new biomarkers that could be useful for other patients with cancer.  The results have the potential to bring significant advantages to physicians as they make individual treatment decisions.”

“BostonGene is thrilled to collaborate with the Weinstock Laboratory at Dana- Farber Cancer Institute, Inc.” said Andrew Feinberg, President and CEO of BostonGene. “Our sophisticated analysis of RNAseq and exome sequencing will identify genomic and transcriptional alterations that could serve as predictive biomarkers of response and resistance to PI3 kinase inhibition that could ultimately improve patient outcomes. “

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About BostonGene Corporation

BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient’s individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGene’s mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies. For more information, visit BostonGene at http://www.BostonGene.com.

 

Media Contacts:

BostonGene
Erin O’Reilly
+1-781-366-7049
Erin.Oreilly@BostonGene.com

 

BostonGene and NEC Collaborate to Analyze Cancer Patients in Clinical Trials

Integrated Genomic and Transcriptomic Next Generation Sequencing (NGS) Data to Reveal Cellular Content of Tumor Microenvironment

WALTHAM, MA, US and Tokyo, Japan – July 20, 2020 – BostonGene Corporation (BostonGene), a biomedical software company focused on defining optimal precision medicine-based therapies for cancer patients, and NEC Corporation (NEC; TSE: 6701), a leader in IT and network technologies, today announced a collaboration to conduct cancer patient analysis treated under NEC’s clinical trials.  This collaboration brings together NEC’s artificial intelligence (AI)-driven approach to cancer immunotherapy with BostonGene’s sophisticated analytical tools.  

Under the terms of the collaboration agreement, BostonGene will perform tumor molecular profiling and microenvironment analysis for cancer patients identified in trials by NEC and or NEC affiliates across cancer types and disease stages.  The collaboration aims to provide molecular characterization of patient tumors for improvement of treatment response, both in clinical trial settings and beyond.

BostonGene’s solution integrates next-generation sequencing (NGS) obtained from a patient’s tumor with a reference cohort of data from patients with similar diagnosis, simultaneously analyzing tumor and tumor microenvironment activity.  The solution will identify all significant somatic alterations, protein expression, activity of tumor promoting and suppressing processes, tumor microenvironment cellular composition, tumor heterogeneity, tumor clonality, hereditary predisposition, viral infestation and pharmacogenomics among other molecular features.

“We are very excited to partner with NEC,” said Andrew Feinberg, President and CEO at BostonGene. “The collaboration between NEC and BostonGene demonstrates the combined commitment to delivering truly breakthrough therapies that identify personalized, effective treatments to dramatically improve patients’ chances for survival and quality of life.“ 

We are partnering with BostonGene because of its advanced patient analysis services,” said Osamu Fujikawa, Senior Vice President at NEC Corporation. “The strategic collaboration with BostonGene is reflective of our mission to improve cancer patient outcomes. BostonGene’s innovative data analytics platform combined with NEC’s cutting-edge AI technology gives us the tools needed to focus on advancing treatment options for cancer patients.”


About BostonGene Corporation 

BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient’s individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGene’s mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies. For more information, visit BostonGene at http://www.BostonGene.com.

About NEC Corporation 

NEC Corporation has established itself as a leader in the integration of IT and network technologies while promoting the brand statement of “Orchestrating a brighter world.” NEC enables businesses and communities to adapt to rapid changes taking place in both society and the market as it provides for the social values of safety, security, fairness and efficiency to promote a more sustainable world where everyone has the chance to reach their full potential. For more information, visit NEC at http://www.nec.com

Media Contacts:

BostonGene
Erin O’Reilly
+1-781-366-7049
Erin.Oreilly@BostonGene.com

NEC Corporation
Joseph Jasper
+81-3-3798-6511
j-jasper@nec.com

BostonGene to Present Three Abstracts at the 2020 American Association for Cancer Research (AACR) Annual Meeting

Abstracts Underscore the Importance of Advanced Molecular Profiling and Analytical Tools for Optimal Precision Medicine and Clinical treatment Design

WALTHAM, MA, June 3, 2020 — BostonGene Corporation, a biomedical software company focused on defining optimal precision medicine-based therapies for cancer patients, today announced that three abstracts were selected for poster presentations at the 2020 American Association for Cancer Research (AACR) Virtual Annual Meeting II, which will be conducted from June 22 – 24, 2020.

The presentations describe findings obtained by using BostonGene’s technologies and analytical tools designed to improve diagnosis and treatment decisions for cancer patients. Results include validation of bulk RNAseq utility for accurate reconstruction of tumor microenvironment and identification of four prominent microenvironment types conserved among solid tumors. Application of BostonGene computational tools lead to better understanding of the role of microenvironment compartments in tumor pathogenesis and supporting clinical decision making for the treatment of cancer.

“We are excited to present at the 2020 AACR Virtual Annual Meeting to share the clinical utility of the BostonGene solution and demonstrate how it improves diagnosis and treatment decisions for cancer patients,” said Andrew Feinberg, President and CEO of BostonGene.

Details of the poster presentations are as follows:

Abstract Number: 6168
Title: Integrated whole exome and transcriptome analyses of the tumor and microenvironment provide new opportunities for rational design of cancer therapy
Session: Tumor Heterogeneity and Microenvironment: Next-Generation Sequencing, Single Cell, and Imaging
Poster: 4418
Presenter: Alexander Bagaev, BostonGene

BostonGene developed and validated a new analytic platform for multi-parametric analyses of malignant and nonmalignant tumor compartments using genomic and transcriptomic sequencing data. Application of BostonGene platform to more than 8,500 patient data sets revealed four types of tumor microenvironment (TME) that are conserved across cancer types and demonstrate high prognostic significance and differential response to immunotherapy. This novel Molecular-Functional (MF) portrait platform, involving analytic and visualization methods, provides a robust tool for prediction of response to immunotherapy and for future tailoring of personalized therapeutic combinations.

Abstract Number: 6997
Title:  Novel machine learning based deconvolution algorithm results in accurate description of tumor microenvironment from bulk RNAseq
Session: Machine Learning and Artificial Intelligence for Omics, Imaging, and Diagnostics
Poster: 853
Presenter: Alexander Bagaev, BostonGene

BostonGene developed a novel machine learning-based algorithm for cellular deconvolution of tumor microenvironment (TME) from bulk RNAseq data. This tool accurately reconstructs proportions of major immune and stromal cell populations, as well as T cell subtypes and M1 and M2 macrophages. Validation of BostonGene algorithm performance by comparison of flow cytometry, single cell RNAseq and bulk RNAseq analysis performed on samples from different tissues will be presented. The result demonstrates utility of bulk RNAseq for accurate and robust reconstruction of TME composition and paves the road for application of the BostonGene computational tool for support of clinical decision making for the treatment of cancer.

Research conducted with Massachusetts General Hospital

Abstract Number: 7544
Title: HER2 expression and M2-like tumor infiltrating macrophages associated with Cabazitaxel activity in gastric cancer
Session: Predictive Biomarkers for Treatment Efficacy 1
Poster: 2011
Presenter: Sandipto Sarkar, Weill Cornell Medicine

In the clinical study of cabazitaxel efficacy in gastric cancer, comprehensive whole exome sequencing (WES) and RNAseq data analysis identified genetic aberrations and tumor microenvironment signatures associated with favorable response. In particular, this analysis resulted in identification of two novel biomarkers, HER2 overexpression and M2-high tumor macrophage signature, both of which associated with improved outcomes. RNAseq-based deconvolution demonstrating M2 macrophages enrichment in patients with improved PFS, was further validated by immunohistochemistry using M1 and M2 macrophage-specific markers.

Research conducted with Weill Cornell Medicine

The e-poster website will be launched June 22, 2020, the first day of the AACR Virtual Annual Meeting II.  All e-posters will be made available for browsing on this date.

Additionally the abstracts will be published in an online-only Proceedings supplement to the AACR journal Cancer Research after the completion of the AACR Virtual Annual Meeting II.

About BostonGene Corporation
BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient’s individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGene’s mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies. For more information, visit BostonGene at http://www.BostonGene.com.

Media Contacts:
BostonGene
Erin O’Reilly
+1-781-366-7049
Erin.Oreilly@BostonGene.com

BostonGene Announces Acceptance of Seven Abstracts to the Annual Meeting of the American Society of Clinical Oncology 2020

Abstracts Underscore the Results of Collaborations with Multiple Leading Cancer Centers in the United States

WALTHAM, MA, May 19, 2020 — BostonGene Corporation, a biomedical software company focused on defining optimal, precision medicine-based therapies for cancer patients, today announced that, as a result of its strategic collaborations, seven abstracts have been accepted to the American Society of Clinical Oncology (ASCO) Annual Meeting.  All abstracts to be published in the Journal of Clinical Oncology supplement for the ASCO Annual Meeting Proceedings.

“We are honored to have multiple abstracts accepted by ASCO 2020. The studies demonstrate the clinical utility of BostonGene‘s advanced precision medicine capabilities and our commitment to transform the lives of cancer patients,” said Andrew Feinberg, President & CEO at BostonGene.

Details of abstract presentations are as follows:

Abstract Number: 8055*
Title: “Multi-omics analysis of mantle cell lymphoma reveals an immune-cold tumor microenvironment associated with ibrutinib resistance”
Session: Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia
Presenter: Krystle Nomie, PhD, BostonGene
Poster: 388

Tumor-immune molecular programs were characterized from over 200 mantle cell lymphoma samples and correlated with response to ibrutinib.

Research conducted with The University of Texas MD Anderson Cancer Center

Abstract Number: 6561*
Title: “Immune functional portraits of head and neck cancer using next generation sequencing”
Session: Head and Neck Cancer
Presenter: Susan Raju Paul, MBBS, Vaccine and Immunotherapy Center, Massachusetts General Hospital
Poster: 222

BostonGene’s comprehensive, integrated analysis of WES and RNAseq was used to characterize the cellular composition and functional state of over 1,400 head and neck tumors and their tumor microenvironment.

Research conducted with Massachusetts General Hospital

Abstract Number: 8054*
Title: “Identification of Predicted Neoantigen Vaccine Candidates in Follicular Lymphoma Patients”
Session: Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia
Presenter: Cody Ramirez at Washington University in St Louis
Poster: 387

Tumor-specific mutant antigens (TSMAs) that can be targeted by vaccination were studied in follicular lymphoma patients and led to a first-in-human pilot trial of a personalized TSMA vaccine combined with immunotherapy.

Research conducted with Washington University in St Louis

Abstract Number: e20065
Title: “Correlation of PI3K upregulation with NOTCH2 mutations in ibrutinib-resistant mantle cell lymphoma”
First Author: Krystle Nomie, PhD, BostonGene

Research conducted with The University of Texas MD Anderson Cancer Center

Abstract Number: e21026
Title: “Non-small cell lung cancer: Analysis using mass cytometry and next generation sequencing reveals new opportunities for the development of personalized therapies”
First Author: Susan Raju Paul, MBBS, Vaccine and Immunotherapy Center, Massachusetts General Hospital

Research conducted with Massachusetts General Hospital

Abstract Number: e17106
Title: “Integrated single-cell spatial multi-omics of intratumor heterogeneity in renal cell carcinoma”
First Author: James Hsieh, MD, PhD at Washington University in St. Louis

Research conducted with Washington University in St Louis

Abstract Number:  e17506
Title: “Integrated-omics of MRI-visible and -invisible prostate cancer identifies molecular correlations with clinical outcome”
First Author: Eric H. Kim, MD at Washington University in St. Louis

Research conducted with Washington University in St Louis

*Abstracts to be presented as posters at the 2020 ASCO Annual Virtual Meeting from May 29-31, 2020

About BostonGene Corporation
BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient’s individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGene’s mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies. For more information, visit BostonGene at http://www.BostonGene.com.

Media Contacts:
BostonGene
Erin O’Reilly
+1-781-366-7049
Erin.Oreilly@BostonGene.com

 

BostonGene and Washington University in St. Louis Collaborate on Kidney Cancer Research

Ongoing Studies to Analyze Tumor and Tumor Microenvironment Molecular Composition of Renal Cell Carcinoma

WALTHAM, MA – April 30, 2020 – BostonGene Corporation, a biomedical software company focused on defining optimal precision medicine-based therapies for cancer patients, today announced it has expanded its research collaboration with Washington University in St. Louis to study renal cell carcinoma (RCC).

This collaboration will evaluate the role tumor microenvironment in RCC progression and treatment response for early stage, as well as metastatic RCC patients treated with approved immune checkpoint inhibitors (ICIs) and targeted agents. As part of this program, BostonGene will perform integrated analysis of multi-platform data generated by multiplex immunofluorescence microscopy (MxIF), whole exome sequencing (WES), whole transcriptome sequencing (RNA-seq), single nuclei RNA-seq (snRNA-seq), whole genome bisulfite sequencing (WGBS), cytometry (CyTOF) and conventional clinical tests like tumor PD-L1 expression, blood cell count and biochemistry.

BostonGene’s software uses a set of unique deconvolution algorithms that reveal cellular content of a tumor and surrounding microenvironment using transcriptome next generation sequencing (NGS) data. Addition of the image analysis component elucidates cellular architecture and spatial localization of tumor, immune and stromal cells. High concordance observed among these technologies suggests that tumor NGS analysis involving WES/RNAseq using BostonGene analytical tools may be utilized for treatment decision support and can be clinically applicable for ccRCC.

Although some RCC patients respond to targeted or immunotherapies, treatment support tools that allow better prediction of response, remain an unmet need.  BostonGene’s comprehensive analysis of RCC tumors and their microenvironment brings an optimal personalized solution predicting the benefits of a particular treatment regime based on the integrated analysis of NGS, imaging and other molecular-level data collected from a primary tumor, metastatic sites and circulating blood.

“We’re collaborating with BostonGene to evaluate how its technology, which includes the integrated analysis of NGS and Multiplex immunofluorescence imaging, can be applied to help make treatment decisions for individual patients with renal cell carcinoma and ultimately improve patient outcomes,” said James Hsieh, MD, PhD, a medical oncologist and Professor of Medicine at Washington University School of Medicine in St Louis.

“We are excited to expand our partnership with Washington University to develop personalized solutions for kidney cancer patients by integrating molecular and clinical information about the individual patient disease with prior knowledge base accumulated from patients with similar diagnosis”, said Andrew Feinberg, President & CEO at BostonGene.

About BostonGene Corporation
BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient’s individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGene’s mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies. For more information, visit BostonGene at http://www.BostonGene.com.

Media Contacts:
BostonGene
Erin O’Reilly
+1-781-366-7049
Erin.Oreilly@BostonGene.com

BostonGene Announces Appointment of Nathan Fowler, M.D., as Chief Medical Officer

Fowler to Provide Strategic Direction for BostonGene in its Mission to Cure Cancer

WALTHAM, MA – February 27, 2020 – BostonGene Corporation, a biomedical software company, today announced the appointment of Nathan Fowler, M.D., to the newly created position of Chief Medical Officer (CMO). Dr. Fowler joins BostonGene as it moves into the advanced stages of commercializing its personalized medicine solutions.

Dr. Fowler brings more than 20 years of patient care experience to BostonGene—most recently as a Professor of Medicine in the Department of Lymphoma/Myeloma at the University of Texas, MD Anderson Cancer Center. In addition to his role as CMO at BostonGene, Dr. Fowler will retain his affiliation with MD Anderson, continuing his involvement in the treatment of lymphoma patients while furthering his clinical research.

“We’re thrilled to welcome Dr. Fowler to BostonGene as a senior member of our management team,” said Andrew Feinberg, President and CEO at BostonGene. “His extensive experience researching and developing new therapies, combined with his commitment to discovering innovative solutions to treat patients, is invaluable to BostonGene as we continue to develop our solutions designed to treat the person, not the diagnosis.”

“I am honored to join BostonGene as its Chief Medical Officer,” said Nathan Fowler, M.D. “I have devoted my entire medical career to finding innovative solutions for cancer treatment, and I firmly believe BostonGene’s solution is fundamentally going to change how we treat cancer patients. I look forward to working with cancer centers from around the globe to drive change and improve the outcomes of all patients battling cancer.”

Dr. Fowler received his medical degree from the University of Texas, having completed his internship and residency there as well. He went on to complete a fellowship in hematology/oncology at Georgetown University Hospital in Washington D.C. At MD Anderson Cancer Center, Dr. Fowler focused on developing groundbreaking new therapies for cancer patients and led the clinical research program for nearly ten years. He is considered one of the world’s foremost experts in drug development for blood cancers, and his direct work led to the FDA approval of several novel agents in lymphoma. He also led development of one of the first combination immunotherapy regimens for untreated lymphomas, and is the primary investigator for the ongoing international phase III study with the combination.

Dr. Fowler has published over 150 articles in peer-reviewed journals as well as numerous textbooks on innovative approaches to cancer therapy. Prior to his work in medicine, Dr. Fowler served in the U.S. Army as a nuclear, biological and chemical defense specialist. In addition, he serves as the President and Founder of Halo House Foundation, a non-profit organization providing housing to blood cancer patients receiving treatment.

About BostonGene Corporation
BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient’s individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGene’s mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies. For more information, visit BostonGene at http://www.BostonGene.com.

Media Contacts:
BostonGene
Erin O’Reilly
+1-781-366-7049
Erin.Oreilly@BostonGene.com