BostonGene Tumor Portrait™ Tests

The BostonGene Tumor Portrait™ Test, a sophisticated analysis of the tumor and tumor microenvironment (TME), reveals critical drivers of each tumor, including immune microenvironment properties, actionable mutations, biomarkers of response to diverse therapies, and recommended therapies.

The BostonGene Tumor Portrait™ test uses DNA whole exome (WES) and RNA transcriptome (RNAseq) sequencing to detect genomic alterations such as single nucleotide variants (SNV), indels, copy number alterations (CNA), tumor mutational burden (TMB), microsatellite instability (MSI), expressed fusions, frameshifts, as well interrogate the expression levels of more than 20,000 genes.

BostonGene integrated genomic and transcriptomic analysis, in concert with the patient’s clinical history, provides information regarding the likely benefits of therapies or therapeutic combinations, suitable NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) treatment recommendations, and ongoing clinical trials.

The BostonGene Tumor Portrait™ Test combines precise data-processing and proprietary algorithms to generate easy-to-understand tumor schematics, the Molecular Functional Portrait™ (Cancer Cell, 2021 Jun 14;39(6):845-865.e7), a personalized tumor map to guide treatment decision-making. Tailoring individualized treatments helps select most effective therapy, avoid unnecessary side effects and decrease treatment costs. The BostonGene Tumor Portrait™ module predicts patient response to immunotherapy and stratifies patients into responders and non-responders.. For patients classified as non-responders to immunotherapy, the BostonGene Tumor Portrait™ Test provides other potential therapy options, utilizing existing guidelines to equip the treating doctor in selecting the ideal therapy route.


BostonGene works directly with oncologists, care teams, surgeons and pathologists to assist with every step of the process from test request placement to request delivery. We provide kits that include everything you need for specimen collection and shipping.

Please contact us to learn more about BostonGene tests, order kits or obtain information about clinical trial solutions.


Test Requisition Form
Consent Form


BostonGene requires normal (blood or saliva) and tumor specimens accepting Formalin-Fixed Paraffin-Embedded (FFPE) or fresh/fresh frozen (FF) tissue.


Analysis are performed in the BostonGene Laboratory that is certified under the Clinical Laboratory Improvement Amendments (CLIA) and accredited by the College of American Pathologists (CAP) as qualified to perform high complexity clinical laboratory testing.

BostonGene tests focused on individual cancer types provide findings relevant for a patient disease.


Adrenocortical Cancer

Breast Cancer

Cervical Cancer

Cutaneous Melanoma

CNS Cancer

Colorectal Cancer

Esophageal Cancer

Endometrial Cancer


Gastric Cancer

Head and Neck Cancer

Kidney Cancer

Liver Cancer


Ovarian Cancer

Pancreatic Cancer

Prostate Cancer


Rare Cancers

Thyroid Cancer

Urothelial and Bladder Cancer

Unknown Origin Cancers


Acute Myeloid Leukemia

Chronic Lymphocytic Leukemia

Diffuse Large B-Cell Lymphoma

Follicular Lymphoma

High-Grade Lymphoma

Mantle Cell Lymphoma

Multiple Myeloma

Peripheral T-Cell Lymphoma