About BOSTONGENE
BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision-making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient’s individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGene’s mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies via sophisticated analytics and integration of scientific and clinical knowledge.
Position Summary
BostonGene is seeking a Bioinformatics Scientist to participate in research and clinical projects in the area of precision oncology.
Responsibilities
- Participate in the research of oncogenesis and tumor properties integrating WES, WGS, RNAseq, scRNAseq and Imaging data analysis
- Develop algorithms and analyze NGS data (WES, WGS, RNAseq, scRNAseq)
- Study the basics of tumor oncogenesis, while participating in projects aimed to discover personalized biomarkers of therapeutic efficacy
- Analyze tumor biology
- Analyze scientific literature and expand the BostonGene knowledge base on oncogenesis and the tumor’s molecular and cellular characteristics
- Analyze the mechanism of action of drugs at the molecular and cellular level
- Participate in the development of a model to describe molecular and cellular properties of a tumor
Qualifications
- Experience in RNAseq data analysis with the following:
- - Identifying somatic mutations from genomic sequencing data
- - Estimating changes in the copy number of genome elements and their structural rearrangements from sequencing data
- - Evaluating gene expression using various metrics from transcriptome sequencing data and their normalization
- - Analysis and interpretation of differential gene expressions
- - Analysis of the representation and the search for molecular pathways by molecular data of various types
- Knowledge of fundamentals of immunology and cell biology
- Prior working knowledge of molecular biology and cell signaling
- Familiarity of the molecular basics of modern targeted and immune antitumor therapies is encouraged
- Experience with scientific literature and scientific databases
- Previous background in experimental work within biochemistry and molecular biology is preferred
- Experience with Python/pandas, R, GNU coreutils
- MS or PhD in Biological sciences and/or Computer Science