WALTHAM, Mass • 2023-05-23

BostonGene and Sylvester Comprehensive Cancer Center at the University of Miami Announce Collaboration

5 min to read

BostonGene today announced a collaboration with Sylvester Comprehensive Cancer Center to study the tumor microenvironment (TME) and mutational landscape of patients with high-grade B-cell lymphoma (HGBCL)
WALTHAM, Mass - May 23, 2023

BostonGene today announced a collaboration with Sylvester Comprehensive Cancer Center to study the tumor microenvironment (TME) and mutational landscape of patients with high-grade B-cell lymphoma (HGBCL).

Sylvester Comprehensive Cancer Center (Sylvester), South Florida’s only NCI-designated cancer center, is part of the University of Miami Health System and the University of Miami Miller School of Medicine. Sylvester employs more than 2,400 physicians, researchers, and staff who work together to discover, develop, and deliver world-class cancer care.

The study will analyze the TME and translocation status in patients with HGBCL, an aggressive type of B-cell non-Hodgkin lymphoma (NHL) to study how genomics can shape the tumor microenvironment and correlate the genomic landscape and expression differences with clinical outcomes. In this collaboration, BostonGene will perform next-generation sequencing, including whole exome and whole transcriptomic analyses of primary tumors collected from HGBCL patients treated at Sylvester. BostonGene’s computational platform integrates genomic and transcriptomic analyses to simultaneously assess the tumor and microenvironment activity by identifying significant somatic alterations, evaluating gene expression, estimating tumor heterogeneity and classifying the microenvironment.

“We plan to use BostonGene’s platform to enable us to fully understand the molecular profiles of patients with high-grade B-cell lymphoma,” said Juan Alderuccio, M.D., associate professor of medicine and member of the lymphoma program at Sylvester. “We are excited about this collaboration and, with our combined expertise, have the opportunity to identify optimal treatment strategies and improve patient outcomes.”

“We’re honored to collaborate with lymphoma experts at Sylvester Comprehensive Cancer Center,” said Nathan Fowler, MD, Chief Medical Officer at BostonGene. “We firmly believe that our next-generation multi-platform analytics will reveal distinct characteristics that can be utilized to personalize treatment.”

About BostonGene Corporation

BostonGene is a company at the intersection of technology and biology, dedicated to advancing and personalizing cancer medicine. Founded in 2015, BostonGene has continually pushed the boundaries of innovation to improve cancer patient care and accelerate research and drug development through cutting-edge solutions. Leveraging our AI-powered multiomics platform, we digitize and comprehensively analyze the molecular profiles of cancer patients, including the immune system and tumor microenvironment. Our software solutions, indication-specific cancer library and advanced bioanalytics, enable us to discover multiparametric signatures, identify targets, match them to relevant indications for biopharma and recommend the most effective treatments for patients. For more information, visit www.BostonGene.com.

Erin O’Reilly

Senior Director

+1-617-283-2285

Erin.Oreilly@BostonGene.com