BostonGene and Thomas Jefferson University Announce Research Collaboration
A Study to Identify Predictive Correlates and Biomarkers of Response for Patients with Head & Neck Cancer
A Study to Identify Predictive Correlates and Biomarkers of Response for Patients with Head & Neck Cancer
WALTHAM, MA – November 10, 2020 - BostonGene Corporation, a biomedical software company committed to defining optimal precision medicine-based therapies for cancer patients, today announced a research collaboration with Thomas Jefferson University and the Sidney Kimmel Cancer Center – Jefferson Health for a study from the window of opportunity trial of Nivolumab and Tadalafil for patients with squamous cell carcinoma of the head and neck.
The Sidney Kimmel Cancer Center – Jefferson Health, a National Cancer Institute (NCI)-designated clinical cancer center providing cancer care at Thomas Jefferson University Hospital, based in Philadelphia, Pennsylvania, is a clinical and research enterprise with four advanced care hubs located throughout the Greater Philadelphia region and staffed by hundreds of oncology researchers and physicians from around the globe.
The research collaboration aims to evaluate the molecular, cellular and immunologic profiles of head and neck cancer patients treated with Nivolumab and Tadalafil. As part of the collaboration, BostonGene will apply its integrated whole exome and whole transcriptome analysis to simultaneously assess the activity of the tumor and tumor microenvironment of patients at distinct disease stages ranging from localized to metastatic disease. The analysis will include the identification of significant somatic alterations, evaluation of gene expression patterns, estimation of tumor heterogeneity, TCR and BCR repertoires and microenvironment classification among other molecular features.
"Leveraging BostonGene’s detailed analysis will allow us to comprehensively assess the molecular profile of head and neck cancer patients treated with Nivolumab and Tadalafil," said Joseph Curry, MD, Member of the Sidney Kimmel Cancer Center and Associate Professor of Otolaryngology at Thomas Jefferson University. "Using a data analytical approach to evaluate the molecular portrait and tumor microenvironment composition will help us to predict the benefits of the particular combination therapy for each patient.”
“We are excited to work with Thomas Jefferson University and the Sidney Kimmel Cancer Center – Jefferson Health on this study of patients with head and neck cancer to demonstrate the clinical utility of BostonGene’s platform,” said Andrew Feinberg, President and CEO at BostonGene. “The collaboration will validate the use of comprehensive molecular analysis to correlate tumor activity and cellular composition with response to therapy, creating a significant opportunity to improve personalized care for patients with head and neck cancer."
WALTHAM, MA – November 10, 2020 - BostonGene Corporation, a biomedical software company committed to defining optimal precision medicine-based therapies for cancer patients, today announced a research collaboration with Thomas Jefferson University and the Sidney Kimmel Cancer Center – Jefferson Health for a study from the window of opportunity trial of Nivolumab and Tadalafil for patients with squamous cell carcinoma of the head and neck.
The Sidney Kimmel Cancer Center – Jefferson Health, a National Cancer Institute (NCI)-designated clinical cancer center providing cancer care at Thomas Jefferson University Hospital, based in Philadelphia, Pennsylvania, is a clinical and research enterprise with four advanced care hubs located throughout the Greater Philadelphia region and staffed by hundreds of oncology researchers and physicians from around the globe.
The research collaboration aims to evaluate the molecular, cellular and immunologic profiles of head and neck cancer patients treated with Nivolumab and Tadalafil. As part of the collaboration, BostonGene will apply its integrated whole exome and whole transcriptome analysis to simultaneously assess the activity of the tumor and tumor microenvironment of patients at distinct disease stages ranging from localized to metastatic disease. The analysis will include the identification of significant somatic alterations, evaluation of gene expression patterns, estimation of tumor heterogeneity, TCR and BCR repertoires and microenvironment classification among other molecular features.
"Leveraging BostonGene’s detailed analysis will allow us to comprehensively assess the molecular profile of head and neck cancer patients treated with Nivolumab and Tadalafil," said Joseph Curry, MD, Member of the Sidney Kimmel Cancer Center and Associate Professor of Otolaryngology at Thomas Jefferson University. "Using a data analytical approach to evaluate the molecular portrait and tumor microenvironment composition will help us to predict the benefits of the particular combination therapy for each patient.”
“We are excited to work with Thomas Jefferson University and the Sidney Kimmel Cancer Center – Jefferson Health on this study of patients with head and neck cancer to demonstrate the clinical utility of BostonGene’s platform,” said Andrew Feinberg, President and CEO at BostonGene. “The collaboration will validate the use of comprehensive molecular analysis to correlate tumor activity and cellular composition with response to therapy, creating a significant opportunity to improve personalized care for patients with head and neck cancer."
About BostonGene Corporation
BostonGene powers an AI model of tumor and immune biology to deliver disease-level insights and enable precision decision-making across oncology and immune-mediated diseases, spanning drug development and clinical care. By integrating multimodal data, including genomic, transcriptomic, immune, and clinical signals, BostonGene generates biologically grounded intelligence to optimize patient selection, trial design, and therapeutic strategy. This creates a scalable AI decision layer that improves development outcomes and clinical management. BostonGene partners with leading biopharmaceutical organizations and academic institutions to accelerate the delivery of precision therapies while continuously expanding its capabilities across new diseases and complex biological systems. For more information, visit www.BostonGene.com.
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