WALTHAM, MA • 2023-04-11

BostonGene Announces Acceptance of Eight Abstracts to be Presented at the American Association for Cancer Research Annual Meeting 2023

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BostonGene to Present on the Power of Next-generation Immunotherapy Response Prediction Using AI-based Multiomic Data Integration

BostonGene to Present on the Power of Next-generation Immunotherapy Response Prediction Using AI-based Multiomic Data Integration



WALTHAM, MA, April 11, 2023

BostonGene today announced that eight abstracts were selected for poster presentations at the American Association for Cancer Research (AACR) Annual Meeting 2023, which will be held from April 14 – 19, at the Orange County Convention Center in Orlando, FL.  BostonGene will exhibit at booth #1358.

On Sunday, April 16, Alexander Bagaev, PhD, Vice President of Product Development at BostonGene, will deliver a presentation on the power of next-generation immunotherapy response prediction driven by BostonGene’s bioinformatic engine through AI-based multiomic data integration.

BostonGene will present posters that describe the development of novel assays and analytical tools and pipelines to advance precision oncology, including our liquid biopsy platform and cancer of unknown primary (CUP) classifier. BostonGene will also demonstrate ability of comprehensive molecular profiling to identify clinically relevant alterations that can be utilized for treatment decision-making. The presentations highlight the application of BostonGene’s innovative technologies to improve the diagnosis and personalized treatment recommendations for cancer patients.

Details of BostonGene’s presence at the AACR Annual Meeting are below:



Spotlight Theater Presentation:

Title: Next generation immunotherapy response prediction driven by BostonGene’s bioinformatic engine through AI-based multiomic data integration
Date and Time: Sunday, April 16 | 1:30 PM
Location: Spotlight theater C
Speaker: Alexander Bagaev, PhD, Vice President of Product Development, BostonGene

BostonGene uses artificial intelligence and machine learning systems to integrate data from next-generation DNA and RNA sequencing (NGS), multiplex imaging, and flow cytometry to paint a comprehensive portrait of a cancer patient’s tumor and immune system. This 360-degree approach to precision diagnostics requires the deployment of novel analytical solutions.

Poster Presentations:



Title: Use of comprehensive molecular profiling to identify additional clinically-relevant alterations compared to targeted gene panels
Abstract number: 244
Date and Time:  Sunday, April 16 | 1:30 PM – 5:00 PM
Location: Exhibit Hall, Poster Section 9
Presenter: Sandrine Degryse, PhD, BostonGene

Title: Analytical validation of a liquid biopsy test using cell-free circulating tumor DNA for mutational profiling
Abstract number: 1042
Date and Time:  Sunday, April 16 | 1:30 PM – 5:00 PM
Location: Exhibit Hall, Poster Section 42
Presenter: Anastasia Yudina, BostonGene

Title: Integrated analysis of gene expression signatures and AI-based detection of tertiary lymphoid structures and stromal tumor-infiltrating lymphocytes in breast cancer H&E samples
Abstract number: 27
Date and Time:  Tuesday, April 18 | 1:30 PM – 5:00 PM
Location: Exhibit Hall, Poster Section 33
Presenter: Kate Postovalova, PhD, BostonGene

Title: An ML-based tool for predicting tissue of origin for cancer of unknown primary (CUP) based on genomic and transcriptomic data
Abstract number: 5405
Date and Time: Tuesday, April 18 | 1:30 PM – 5:00 PM
Location: Exhibit Hall, Poster Section 32
Presenter: Nara Shin, PhD, BostonGene

Title: Computational cancer cell gene expression deconvolution from tumor bulk RNA-seq via the machine learning algorithm Helenus
Abstract number: 5401
Date and Time:  Tuesday, April 18 | 1:30 PM – 5:00 PM
Location: Exhibit Hall, Poster Section 32
Presenter: Krystle Nomie, PhD, BostonGene

Title: Development and refinement of functional gene expression signatures as a computational tool for comprehensive characterization of transcriptomic data
Abstract number: 6538
Date and Time:  Wednesday, April 19 | 9:00 AM – 12:30 PM
Location: Exhibit Hall, Poster Section 30
Presenter:  Alexander Bagaev, PhD, BostonGene

Title: Comprehensive immunoprofiling of peripheral blood reveals five conserved immunotypes with implications for immunotherapy in cancer patients
Abstract number: 6664
Date and Time:  Wednesday, April 19 | 9:00 AM – 12:30 PM
Location: Exhibit Hall, Poster Section 39
Presenter: Michael Goldberg, PhD, BostonGene

Title: Cancer of unknown primary (CUP): Beyond the identification of the site of origin by an integrative genomic approach
Abstract number: 2143
Date and Time:  Monday, April 17 | 9:00 AM – 12:30 PM
Location: Exhibit Hall, Poster Section 39
Presenter:  Majd Al Assaad, MD, Weill Cornell Medicine

 Research conducted in collaboration with Weill Cornell Medicine

The abstracts will be published in an online-only Proceedings supplement to the AACR journal Cancer Research after the conclusion of the AACR Annual Meeting.

About BostonGene Corporation

BostonGene has a mission to provide transformative, AI-integrated molecular analytics and biomarker discovery for precision matching of therapies to improve the lives of patients living with cancer and other immune-related diseases. BostonGene’s service model provides customized client solutions using a multi-omic approach prioritized for real-world impact, including optimized standard-of-care therapies, accelerated research and cost-effective, measurable results. BostonGene’s tests reveal key drivers of each patient’s unique disease profile, including an in-depth profile of the immune microenvironment, actionable mutations, biomarkers of response to diverse therapies, and recommended therapies. Through these comprehensive analyses, BostonGene’s tests generate a personalized roadmap for therapeutic decision-making for each patient. For more information, visit BostonGene at http://www.BostonGene.com.

Erin O’Reilly

Senior Director

+1-617-283-2285

Erin.Oreilly@BostonGene.com