WALTHAM, MA • 2021-05-11

BostonGene Announces Cancer Research Collaboration with the Abramson Cancer Center of the University of Pennsylvania

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Research Study Aimed at Understanding the Role of Tumor Specific Antigens and Improving Cancer Immunotherapy Treatment Options

Research Study Aimed at Understanding the Role of Tumor Specific Antigens and Improving Cancer Immunotherapy Treatment Options

WALTHAM, MA – May 11, 2021 

BostonGene Corporation, a biomedical software company committed to defining optimal precision medicine-based therapies for cancer patients, today announced a Master Clinical Research Collaboration Agreement with the Abramson Cancer Center (ACC) of the University of Pennsylvania to support multiple research projects at the cancer center.

The first research project to arise from this collaboration aims to support clinical research focusing on personalized cancer vaccines, a new approach of active immunotherapy which utilizes the patient’s own immune system to identify tumor specific neoantigens. BostonGene’s advanced computational algorithms will identify cancer specific neoantigens and profile the immune activation status of the tumor by performing advanced multi-omics analysis, including the interpretation and visualization of cancer patient’s genomic, transcriptomic and imaging datasets. The analysis includes the identification of targetable molecular alterations, evaluation of gene expression and gene signatures, characterization of cellular components in the tumor microenvironment, estimation of tumor heterogeneity, prediction of neoantigens and tumor clonality.

“BostonGene’s strategy is to revolutionize medicine in the quest to identify better, personalized treatment options with successful outcomes,” said Andrew Feinberg, President and CEO at BostonGene. “We are pleased to support the Abramson Cancer Center by providing sophisticated analytics and integration of scientific and clinical knowledge in an effort to improve the standard of care and redefine the treatment selection approach for cancer patients.”

The ACC, a global leader in basic, translational, clinical, and biomedical research for the advancement of cancer care, is a matrix cancer center embedded within the University of Pennsylvania and the University of Pennsylvania Health System.  The ACC, a National Cancer Institute-Designated Comprehensive Cancer Center, is comprised of cancer specialists committed to offering cancer patients the newest and most innovative therapeutic advances.

“We look forward to using BostonGene’s technology to help in our work to better understand the mechanisms of cancer neoantigen recognition and to the discovery of new immunotherapy treatment options,” said Gerald Linette, MD, PhD, a professor of Medicine in the Perelman School of Medicine at the University of Pennsylvania and Clinical Director of the Parker Institute for Cancer Immunotherapy at Penn. “We are excited about this collaboration, and with our combined expertise have an opportunity to make a profound impact on how cancer patients are treated in the future.“

About BostonGene Corporation

BostonGene has a mission to provide transformative, AI-integrated molecular analytics and biomarker discovery for precision matching of therapies to improve the lives of patients living with cancer and other immune-related diseases. BostonGene offers customized client solutions using a multi-omic approach prioritized for real-world impact, optimizing standard-of-care therapies, accelerating research and delivering cost-effective, measurable data-driven results. BostonGene’s tests reveal key drivers of each patient’s unique disease profile, including an in-depth analysis of the immune microenvironment, actionable mutations, biomarkers of response to diverse therapies and recommended treatments. Through these comprehensive analyses, BostonGene’s tests generate a personalized roadmap for therapeutic decision-making for each patient. For more information, visit BostonGene at http://www.BostonGene.com.

Erin O’Reilly

Senior Director