Research Solutions

BostonGene supports scientific research in oncology and immunology. We provide access to a wide spectrum of cutting-edge technologies to help the pharmaceutical industry, the global research community, and biomedical companies develop and validate new approaches in precision medicine.
  • Next-generation sequencing
  • Biomarker discovery and validation
  • Mechanism of action discovery
  • Companion diagnostics with our CDx assay
  • Clinical trial support
  • Analytical services
  • Bioinformatics support
  • Cohort profiling

Molecular Cancer Diagnostics

The BostonGene Tumor Portrait™ Test depicts tumor activity, tumor cellular composition, immune microenvironment activity, and other tumor-associated processes to identify active or suppressed processes in patient tumors to ultimately guide therapeutic decision-making.

Cell-Cell Interaction Analysis

BostonGene analyzes surface receptor expression based on transcriptomic data and deconvolution algorithms to simplify cell-cell interactions.

Neoantigens

BostonGene’s proprietary validated algorithms predict tumor antigenicity and calculate expressed neoantigenic peptides derived from mutated and fusion proteins.

Pathway Analysis

BostonGene analyzes the functional and transcriptomic effects of genomic alterations by utilizing the complete spectrum of protein-protein interactions in a comprehensive map of signaling pathways.

TCR/BCR Repertoire Profiling

BostonGene cancer reactive profiling of T and B cells immune cell repertoire in the tumor microenvironment in solid cancer as well as the identification of major malignant clones of T and B cells in hematological malignancies leads to a better understanding of tumor progression and evolution.

Transcriptomic and Gene Signatures

BostonGene analyzes the expression of all transcripts, single genes, and functional gene signatures to understand multiple aspects of the biology of the tumor and microenvironment.

Tumor Alterations

BostonGene identifies genomic alteration across the entire exome including point mutations, indels, tumor mutational burden (TMB), copy number alteration and HRR gene mutations.

Tumor Heterogeneity

BostonGene assesses the subclonal heterogeneity and evolution of malignant cells within the tissue to understand tumor progression.

Tumor Microenvironment

BostonGene decodes the tumor microenvironment via deconvolution of cellular components by proprietary machine learning algorithms analyzing bulk RNA-seq, enabling the accurate reconstruction of the microenvironment.

Virus & Bacteria Infection Detection

BostonGene detects cancer-associated viral or bacterial infections relevant for diagnostics and therapy selection.