Follicular Lymphoma
Tumor Microenvironment Types
The BostonGene Tumor Microenvironment (TME) types represent the molecular and functional characteristics of a tumor based on transcriptomic data. These TME types reflect the abundance of malignant cells and various subpopulations of TME cells, as well as the activity of tumor-promoting and tumor-suppressive processes occurring within the tumor. The classification is built upon the expression of manually curated gene expression signatures. To learn more about curated gene signatures and association with clinical outcomes, read our publication (PMID: 33541860).
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Immune-enriched,
non-fibrotic
non-fibrotic
The immune-enriched, non-fibrotic type is characterized by medium levels of immune cells and low prevalence of stromal elements. Low levels of myeloid cells, including macrophages, are observed. Angiogenesis is only slightly presented.
Immune-enriched,
mesenchymal
mesenchymal
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The immune-enriched, mesenchymal type is characterized by high prevalence of immune cells, including effector T and NK cells. High expression of immune checkpoint molecules. Intense vascularization and extracellular matrix (ECM) remodeling processes are observed. TGF-β signaling pathway is often upregulated. The percentage of malignant cells is low.
Mesenchymal
The mesenchymal type is characterized by elevated levels of stromal elements. This type is characterized by a high number of follicular dendritic cells, macrophages, and fibroblastic reticular cells. Intense vascularization and extracellular matrix (ECM) remodeling processes are observed. TGF-β signaling pathway is often upregulated. Low tumor proliferation rate.
Immune-depleted
The immune-depleted type contains the highest percentage of malignant cells, leukocyte/lymphocyte infiltration is only minimal or completely absent. High tumor proliferation rate is observed. Low prevalence of stromal elements.
B-cells T-cells NK-cells
Cancer associated fibroblasts
Granulocytes
Endothelium
Macrophages
Tumor cells
