Mantle Cell Lymphoma

Tumor Microenvironment Types

The BostonGene Tumor Microenvironment (TME) types represent the molecular and functional characteristics of a tumor based on transcriptomic data. These TME types reflect the abundance of malignant cells and various subpopulations of TME cells, as well as the activity of tumor-promoting and tumor-suppressive processes occurring within the tumor. The classification is built upon the expression of manually curated gene expression signatures. To learn more about curated gene signatures, read our publication (PMID: 37821434).

Immune-enriched

The immune-enriched type is characterized by medium to high levels of immune infiltration, including cytotoxic effector cells and T follicular helper cells, and low prevalence of stromal and fibrotic elements. JAK-STAT, MAPK and p53 pathways are often activated. Medium tumor proliferation rate is observed.

Normal lymph node-like

The normal lymph node-like type is characterized by high levels of immune infiltration, including both lymphoid and myeloid cells, and low prevalence of malignant cells. High expression of immune checkpoint molecules. High levels of lymphatic endothelium, fibroblastic reticular cells and follicular dendritic cells, but low levels of extracellular matrix are observed. Angiogenesis is high, tumor proliferation rate is commonly low to moderate.

Mesenchymal

The mesenchymal type is characterized by low lymphocyte infiltration and high prevalence of stromal and myeloid elements: follicular dendritic cells, macrophages, fibroblastic reticular cells and extracellular matrix. Angiogenesis is high. NFkB, Hypoxia and MAPK pathways are often upregulated. Low tumor proliferation rate is commonly observed.

Immune-depleted

The Immune-depleted type contains the highest percentage of malignant cells, immune infiltration is only minimal or completely absent. Low prevalence of stromal elements. PI3K pathway is often upregulated. High tumor proliferation rate is commonly observed.

B-cells T-cells NK-cells

Cancer associated fibroblasts

Granulocytes

Endothelium

Macrophages

Tumor cells