Melanoma
Tumor Microenvironment Types
The BostonGene Tumor Microenvironment (TME) types represent the molecular and functional characteristics of a tumor based on transcriptomic data. These TME types reflect the abundance of malignant cells and various subpopulations of TME cells, as well as the activity of tumor-promoting and tumor-suppressive processes occurring within the tumor. The classification is built upon the expression of manually curated gene expression signatures. To learn more about curated gene signatures and association with clinical outcomes, visit science.bostongene.com/gene-signature (PMID: 34019806).
.webp)
Immune-enriched,
non-fibrotic
non-fibrotic
The immune-enriched, non-fibrotic type is characterized by high levels of immune infiltration, including cytotoxic effector cells, high inflammation and low prevalence of stromal and fibrotic elements. High tumor mutational burden (TMB). Immune escape mechanisms are often activated. Mutations in genes associated with the antigen-presentation machinery are frequent.
Immune-enriched, fibrotiс
The immune-enriched, fibrotic type is characterized by high levels of immune infiltration and inflammation, low prevalence of malignant cells with low proliferation rate. High prevalence of stromal and fibrotic elements, cancer-associated fibroblasts (CAF) are abundant. Intense vascularization and low prevalence of aneuploidy are commonly observed.
Immune desert
The immune desert type is characterized by a high percentage of malignant cells, and low or completely absent immune infiltration. This portrait type is commonly non-inflamed, with increased chromosomal instability (CIN), high prevalence of aneuploidy and high tumor proliferation rate.
Fibrotic
The fibrotic type is characterized by minimal immune infiltration and high prevalence of stromal elements, often with dense collagen formation, intense angiogenesis and abundant cancer-associated fibroblasts (CAF). Upregulated TGF-β signaling pathway and signs of epithelial-mesenchymal transition (EMT) are often observed.
B-cells T-cells NK-cells
Cancer associated fibroblasts
Granulocytes
Endothelium
Macrophages
Tumor cells
