Sarcoma
Tumor Microenvironment Types
The BostonGene Tumor Microenvironment (TME) types represent the molecular and functional characteristics of a tumor based on transcriptomic data. These TME types reflect the abundance of malignant cells and various subpopulations of TME cells, as well as the activity of tumor-promoting and tumor-suppressive processes occurring within the tumor. The classification is built upon the expression of manually curated gene expression signatures. To learn more about curated gene signatures, visit science.bostongene.com/gene-signature (PMID: 34019806).
Immune-enriched,
non-fibrotic
non-fibrotic
The immune-enriched, non-fibrotic type is characterized by high levels of immune infiltration, including cytotoxic effector cells, and low prevalence of stromal and fibrotic elements. This portrait type is commonly associated with immune inflammation and high tumor mutational burden (TMB).
Immune-enriched, fibrotiс
The immune-enriched, fibrotiс type is characterized by medium levels of immune infiltration, low prevalence of malignant cells. High prevalence of stromal and fibrotic elements, the percentage of cancer-associated fibroblasts (CAF) is medium. This portrait type is commonly associated with intense vascularization, moderate inflammation and low tumor proliferation rate.
Immune desert
The immune desert type is characterized by a high percentage of malignant cells, and low or completely absent immune infiltration. This portrait type is commonly non-inflamed, with increased chromosomal instability (CIN) and moderate tumor proliferation rate.
Fibrotic
The fibrotic type is characterized by minimal immune infiltration and high prevalence of stromal elements, often with dense collagen formation, moderate angiogenesis and abundant сancer-associated fibroblasts (CAF). This portrait type is commonly non-inflamed, with upregulated TGF-β signaling pathway and pro-tumor cytokine expression.
B-cells T-cells NK-cells
Cancer associated fibroblasts
Granulocytes
Endothelium
Macrophages
Tumor cells
