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Technology: Integrative approach

BostonGene’s AI-powered software platform integrates advanced bioinformatics, next-generation sequencing, flow cytometry and imaging technologies to deliver a comprehensive molecular and cellular understanding. By leveraging proprietary analytical tools and multi-modal data integration, our platform accelerates the development of life-saving therapies.

Transforming cancer care through AI innovation

An end-to-end AI platform for drug development
End-to-end AI drug development platform workflow diagram showing genomic and transcriptomic profiling stages End-to-end AI drug development platform workflow diagram showing genomic and transcriptomic profiling stages

BostonGene integrates complex biological data into a single platform

Our platform achieves exceptional outcomes by effectively leveraging available data and modalities to comprehensively represent the patient.
Organizational levels
  • Molecular
    Molecular mechanisms driving the disease: genomic, transcriptomic and proteomic analysis.
  • Cellular
    Signaling pathway activity within individual cells: TME composition and function
  • Tissue
    Cell-cell interactions and tissue architecture: spatial proteomic and transcriptomic analysis
  • Organism
    The interplay between the tumor and the entire organism: immune system profiling
Data types and modalities
  • Clinical data
    Pathology reports and medical records
  • Genomic
    Genetic variation and inherited heterogeneity
  • Transcriptomic
    Levels of gene expression and activated pathways
  • Proteomic
    Tissue-specific protein profiles
  • Cellular
    Cell composition using digital RNA cytometry
  • Imaging
    Spatial tissue profiling using digital pathology
  • Immunoprofiling
    Components and responses of the immune system
Diverse model applications
  • Simulate complex biological systems and drug response
    Predicting disease progression and patient response to treatment.
  • Increase predictive value of diagnostics for precise patient selection
    Through the parallel utilization of information from multiple modalities.
  • Design clinical trials
    Direct application to specific molecular subtypes to increase the PoS.
Laboratory innovations that power the AI engine
Whole exome sequencing
Unbiased detection of genetic variants across nearly 20,000 genes.
Whole transcriptome sequencing
Precise identification of gene fusions, gene expression levels and expression signatures.
Liquid Biopsy ctDNA, cfRNA
Minimally invasive tumor profiling from a standard blood sample.
scRNA-seq
High-resolution analysis of individual transcriptomes from thousands of cells within a single sample.
Flow cytometry
State-of-the-art flow cytometry solutions to assess immune system status from a standard blood sample.
Spatial proteomics
A comprehensive overview of tissue architecture and cell-cell interactions from a single slide.
Digital pathology
AI-based platform significantly reduces the need for manual analysis across various types of pathology data.
Whole exome sequencing
Unbiased detection of genetic variants across nearly 20,000 genes.
Whole transcriptome sequencing
Precise identification of gene fusions, gene expression levels and expression signatures.
Liquid Biopsy ctDNA, cfRNA
Minimally invasive tumor profiling from a standard blood sample.
scRNA-seq
High-resolution analysis of individual transcriptomes from thousands of cells within a single sample.
Flow cytometry
State-of-the-art flow cytometry solutions to assess immune system status from a standard blood sample.
Spatial proteomics
A comprehensive overview of tissue architecture and cell-cell interactions from a single slide.
Digital pathology
AI-based platform significantly reduces the need for manual analysis across various types of pathology data.
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Publications

Nature • October 18, 2023
Clinical trial links oncolytic immunoactivation to survival...
Cancer Cell • May 14, 2024
Comprehensive peripheral blood immunoprofiling...
Cancer Cell • February 29, 2024
Multiomic profiling of follicular lymphoma...
Gastroenterology • May 6, 2024
Transcriptomic-based tumor microenvironment classification...
Learn more about the scientific power of BostonGene

Partners

BostonGene collaborates with leading cancer centers, offering innovative technologies.

Publications

The landmark research conducted by BostonGene highlights the significance of integrating innovative multi-platform analytics with cutting-edge software to improve patient outcomes.

Awards

BostonGene has received numerous recognitions and accolades for our outstanding contributions to the industry, showcasing the innovation, expertise, and commitment that define our identity.
Helpful resources
Analytical and clinical capabilities Clinical research solutions Laboratory capabilities Solutions for patients stratification and research Kassandra™ BostonGene PAM50 Discovery solutions sample requirements Spatial proteomics